Serveur d'exploration sur la COVID chez les séniors

Attention, ce site est en cours de développement !
Attention, site généré par des moyens informatiques à partir de corpus bruts.
Les informations ne sont donc pas validées.

Time Length of Negativization and Cycle Threshold Values in 182 Healthcare Workers with Covid-19 in Milan, Italy: An Observational Cohort Study.

Identifieur interne : 000121 ( Main/Exploration ); précédent : 000120; suivant : 000122

Time Length of Negativization and Cycle Threshold Values in 182 Healthcare Workers with Covid-19 in Milan, Italy: An Observational Cohort Study.

Auteurs : Lisa Cariani [Italie] ; Beatrice Silvia Orena [Italie] ; Federico Ambrogi [Italie] ; Simone Gambazza [Italie] ; Anna Maraschini [Italie] ; Antonella Dodaro [Italie] ; Massimo Oggioni [Italie] ; Annarosa Orlandi [Italie] ; Alessia Pirrone [Italie] ; Sara Uceda Renteria [Italie] ; Mara Bernazzani [Italie] ; Anna Paola Cantù [Italie] ; Ferruccio Ceriotti [Italie] ; Giovanna Lunghi [Italie]

Source :

RBID : pubmed:32718008

Descripteurs français

English descriptors

Abstract

Background: Coronavirus Disease 2019 (COVID-19) has rapidly spread worldwide, becoming an unprecedented public health emergency. Rapid detection of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) suspected cases is crucial to control the spread of infection. We aimed to evaluate the time length of negativization from the onset of symptoms in healthcare workers (HCWs) with COVID-19, and to evaluate significant variations in cycle threshold (CT) values and gene positivity (E, RdRP, and N genes) among positive individuals who returned to work. Methods: We retrospectively analyzed a consecutive cohort of 182 SARS-CoV-2-positive HCWs in Milan, from 16 March to 30 April 2020. Nasopharyngeal swabs were tested by RT-PCR. Results: Asymptomatic HCWs were 17.6% (32/182), and 58 healed at 30 April 2020. The median time length of negativization was 4 weeks (35% of symptomatic versus 40% of asymptomatic HCWs). Four HCWs, healed at 30 April, turned positive within three weeks during controls set up in the work unit. Three-gene positivity had the greatest variability, and increasing CT values from single- to three-gene positivity among all age groups were observed. Conclusions: Self-isolation longer than two weeks and prolonged follow-up periods for the staff returning to work after COVID-19 could be the most suitable choices to counter the SARS-CoV-2 spread. Further studies are needed to investigate infectiousness profiles among positive individuals.

DOI: 10.3390/ijerph17155313
PubMed: 32718008
PubMed Central: PMC7432921


Affiliations:


Links toward previous steps (curation, corpus...)


Le document en format XML

<record>
<TEI>
<teiHeader>
<fileDesc>
<titleStmt>
<title xml:lang="en">Time Length of Negativization and Cycle Threshold Values in 182 Healthcare Workers with Covid-19 in Milan, Italy: An Observational Cohort Study.</title>
<author>
<name sortKey="Cariani, Lisa" sort="Cariani, Lisa" uniqKey="Cariani L" first="Lisa" last="Cariani">Lisa Cariani</name>
<affiliation wicri:level="1">
<nlm:affiliation>Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Microbiology Unit, 20122 Milan, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Microbiology Unit, 20122 Milan</wicri:regionArea>
<placeName>
<settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Orena, Beatrice Silvia" sort="Orena, Beatrice Silvia" uniqKey="Orena B" first="Beatrice Silvia" last="Orena">Beatrice Silvia Orena</name>
<affiliation wicri:level="1">
<nlm:affiliation>Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Microbiology Unit, 20122 Milan, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Microbiology Unit, 20122 Milan</wicri:regionArea>
<placeName>
<settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
<affiliation wicri:level="1">
<nlm:affiliation>Specialization School in Microbiology and Virology, University of Milan, 20142 Milan, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Specialization School in Microbiology and Virology, University of Milan, 20142 Milan</wicri:regionArea>
<placeName>
<settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Ambrogi, Federico" sort="Ambrogi, Federico" uniqKey="Ambrogi F" first="Federico" last="Ambrogi">Federico Ambrogi</name>
<affiliation wicri:level="1">
<nlm:affiliation>Laboratory of Medical Statistics and Biometry, Giulio A. Maccacaro, Department of Clinical Sciences and Community Health, Campus Cascina Rosa, University of Milan, 20133 Milan, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Laboratory of Medical Statistics and Biometry, Giulio A. Maccacaro, Department of Clinical Sciences and Community Health, Campus Cascina Rosa, University of Milan, 20133 Milan</wicri:regionArea>
<placeName>
<settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Gambazza, Simone" sort="Gambazza, Simone" uniqKey="Gambazza S" first="Simone" last="Gambazza">Simone Gambazza</name>
<affiliation wicri:level="1">
<nlm:affiliation>Laboratory of Medical Statistics and Biometry, Giulio A. Maccacaro, Department of Clinical Sciences and Community Health, Campus Cascina Rosa, University of Milan, 20133 Milan, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Laboratory of Medical Statistics and Biometry, Giulio A. Maccacaro, Department of Clinical Sciences and Community Health, Campus Cascina Rosa, University of Milan, 20133 Milan</wicri:regionArea>
<placeName>
<settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
<affiliation wicri:level="1">
<nlm:affiliation>UOC Direzione Professioni Sanitarie, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>UOC Direzione Professioni Sanitarie, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan</wicri:regionArea>
<placeName>
<settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Maraschini, Anna" sort="Maraschini, Anna" uniqKey="Maraschini A" first="Anna" last="Maraschini">Anna Maraschini</name>
<affiliation wicri:level="1">
<nlm:affiliation>Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Microbiology Unit, 20122 Milan, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Microbiology Unit, 20122 Milan</wicri:regionArea>
<placeName>
<settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Dodaro, Antonella" sort="Dodaro, Antonella" uniqKey="Dodaro A" first="Antonella" last="Dodaro">Antonella Dodaro</name>
<affiliation wicri:level="1">
<nlm:affiliation>Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Microbiology Unit, 20122 Milan, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Microbiology Unit, 20122 Milan</wicri:regionArea>
<placeName>
<settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Oggioni, Massimo" sort="Oggioni, Massimo" uniqKey="Oggioni M" first="Massimo" last="Oggioni">Massimo Oggioni</name>
<affiliation wicri:level="1">
<nlm:affiliation>Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Virology Unit, 20122 Milan, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Virology Unit, 20122 Milan</wicri:regionArea>
<placeName>
<settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Orlandi, Annarosa" sort="Orlandi, Annarosa" uniqKey="Orlandi A" first="Annarosa" last="Orlandi">Annarosa Orlandi</name>
<affiliation wicri:level="1">
<nlm:affiliation>Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Virology Unit, 20122 Milan, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Virology Unit, 20122 Milan</wicri:regionArea>
<placeName>
<settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Pirrone, Alessia" sort="Pirrone, Alessia" uniqKey="Pirrone A" first="Alessia" last="Pirrone">Alessia Pirrone</name>
<affiliation wicri:level="1">
<nlm:affiliation>Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Microbiology Unit, 20122 Milan, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Microbiology Unit, 20122 Milan</wicri:regionArea>
<placeName>
<settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Uceda Renteria, Sara" sort="Uceda Renteria, Sara" uniqKey="Uceda Renteria S" first="Sara" last="Uceda Renteria">Sara Uceda Renteria</name>
<affiliation wicri:level="1">
<nlm:affiliation>Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Virology Unit, 20122 Milan, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Virology Unit, 20122 Milan</wicri:regionArea>
<placeName>
<settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Bernazzani, Mara" sort="Bernazzani, Mara" uniqKey="Bernazzani M" first="Mara" last="Bernazzani">Mara Bernazzani</name>
<affiliation wicri:level="1">
<nlm:affiliation>Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Responsabile Infermieristico area Direzione Medica di Presidio, Coordinamento dipartimenti clinici, Servizio Prevenzione Igiene Ospedaliera, 20122 Milan, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Responsabile Infermieristico area Direzione Medica di Presidio, Coordinamento dipartimenti clinici, Servizio Prevenzione Igiene Ospedaliera, 20122 Milan</wicri:regionArea>
<placeName>
<settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Cantu, Anna Paola" sort="Cantu, Anna Paola" uniqKey="Cantu A" first="Anna Paola" last="Cantù">Anna Paola Cantù</name>
<affiliation wicri:level="1">
<nlm:affiliation>Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Direzione Medica di Presidio, 20122 Milan, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Direzione Medica di Presidio, 20122 Milan</wicri:regionArea>
<placeName>
<settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
<affiliation wicri:level="1">
<nlm:affiliation>Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Romeo ed Enrica Invernizzi Paediatric Research Centre, Department of Biosciences, University of Milan, 20122 Milan, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Romeo ed Enrica Invernizzi Paediatric Research Centre, Department of Biosciences, University of Milan, 20122 Milan</wicri:regionArea>
<placeName>
<settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Ceriotti, Ferruccio" sort="Ceriotti, Ferruccio" uniqKey="Ceriotti F" first="Ferruccio" last="Ceriotti">Ferruccio Ceriotti</name>
<affiliation wicri:level="1">
<nlm:affiliation>Fondazione IRCCS Ca' Granda Ospedale Maggiore, Clinical Laboratory, 20122 Milan, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Fondazione IRCCS Ca' Granda Ospedale Maggiore, Clinical Laboratory, 20122 Milan</wicri:regionArea>
<placeName>
<settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Lunghi, Giovanna" sort="Lunghi, Giovanna" uniqKey="Lunghi G" first="Giovanna" last="Lunghi">Giovanna Lunghi</name>
<affiliation wicri:level="1">
<nlm:affiliation>Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Virology Unit, 20122 Milan, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Virology Unit, 20122 Milan</wicri:regionArea>
<placeName>
<settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt>
<idno type="wicri:source">PubMed</idno>
<date when="2020">2020</date>
<idno type="RBID">pubmed:32718008</idno>
<idno type="pmid">32718008</idno>
<idno type="doi">10.3390/ijerph17155313</idno>
<idno type="pmc">PMC7432921</idno>
<idno type="wicri:Area/Main/Corpus">000984</idno>
<idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000984</idno>
<idno type="wicri:Area/Main/Curation">000984</idno>
<idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000984</idno>
<idno type="wicri:Area/Main/Exploration">000984</idno>
</publicationStmt>
<sourceDesc>
<biblStruct>
<analytic>
<title xml:lang="en">Time Length of Negativization and Cycle Threshold Values in 182 Healthcare Workers with Covid-19 in Milan, Italy: An Observational Cohort Study.</title>
<author>
<name sortKey="Cariani, Lisa" sort="Cariani, Lisa" uniqKey="Cariani L" first="Lisa" last="Cariani">Lisa Cariani</name>
<affiliation wicri:level="1">
<nlm:affiliation>Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Microbiology Unit, 20122 Milan, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Microbiology Unit, 20122 Milan</wicri:regionArea>
<placeName>
<settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Orena, Beatrice Silvia" sort="Orena, Beatrice Silvia" uniqKey="Orena B" first="Beatrice Silvia" last="Orena">Beatrice Silvia Orena</name>
<affiliation wicri:level="1">
<nlm:affiliation>Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Microbiology Unit, 20122 Milan, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Microbiology Unit, 20122 Milan</wicri:regionArea>
<placeName>
<settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
<affiliation wicri:level="1">
<nlm:affiliation>Specialization School in Microbiology and Virology, University of Milan, 20142 Milan, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Specialization School in Microbiology and Virology, University of Milan, 20142 Milan</wicri:regionArea>
<placeName>
<settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Ambrogi, Federico" sort="Ambrogi, Federico" uniqKey="Ambrogi F" first="Federico" last="Ambrogi">Federico Ambrogi</name>
<affiliation wicri:level="1">
<nlm:affiliation>Laboratory of Medical Statistics and Biometry, Giulio A. Maccacaro, Department of Clinical Sciences and Community Health, Campus Cascina Rosa, University of Milan, 20133 Milan, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Laboratory of Medical Statistics and Biometry, Giulio A. Maccacaro, Department of Clinical Sciences and Community Health, Campus Cascina Rosa, University of Milan, 20133 Milan</wicri:regionArea>
<placeName>
<settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Gambazza, Simone" sort="Gambazza, Simone" uniqKey="Gambazza S" first="Simone" last="Gambazza">Simone Gambazza</name>
<affiliation wicri:level="1">
<nlm:affiliation>Laboratory of Medical Statistics and Biometry, Giulio A. Maccacaro, Department of Clinical Sciences and Community Health, Campus Cascina Rosa, University of Milan, 20133 Milan, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Laboratory of Medical Statistics and Biometry, Giulio A. Maccacaro, Department of Clinical Sciences and Community Health, Campus Cascina Rosa, University of Milan, 20133 Milan</wicri:regionArea>
<placeName>
<settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
<affiliation wicri:level="1">
<nlm:affiliation>UOC Direzione Professioni Sanitarie, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>UOC Direzione Professioni Sanitarie, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan</wicri:regionArea>
<placeName>
<settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Maraschini, Anna" sort="Maraschini, Anna" uniqKey="Maraschini A" first="Anna" last="Maraschini">Anna Maraschini</name>
<affiliation wicri:level="1">
<nlm:affiliation>Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Microbiology Unit, 20122 Milan, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Microbiology Unit, 20122 Milan</wicri:regionArea>
<placeName>
<settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Dodaro, Antonella" sort="Dodaro, Antonella" uniqKey="Dodaro A" first="Antonella" last="Dodaro">Antonella Dodaro</name>
<affiliation wicri:level="1">
<nlm:affiliation>Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Microbiology Unit, 20122 Milan, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Microbiology Unit, 20122 Milan</wicri:regionArea>
<placeName>
<settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Oggioni, Massimo" sort="Oggioni, Massimo" uniqKey="Oggioni M" first="Massimo" last="Oggioni">Massimo Oggioni</name>
<affiliation wicri:level="1">
<nlm:affiliation>Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Virology Unit, 20122 Milan, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Virology Unit, 20122 Milan</wicri:regionArea>
<placeName>
<settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Orlandi, Annarosa" sort="Orlandi, Annarosa" uniqKey="Orlandi A" first="Annarosa" last="Orlandi">Annarosa Orlandi</name>
<affiliation wicri:level="1">
<nlm:affiliation>Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Virology Unit, 20122 Milan, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Virology Unit, 20122 Milan</wicri:regionArea>
<placeName>
<settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Pirrone, Alessia" sort="Pirrone, Alessia" uniqKey="Pirrone A" first="Alessia" last="Pirrone">Alessia Pirrone</name>
<affiliation wicri:level="1">
<nlm:affiliation>Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Microbiology Unit, 20122 Milan, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Microbiology Unit, 20122 Milan</wicri:regionArea>
<placeName>
<settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Uceda Renteria, Sara" sort="Uceda Renteria, Sara" uniqKey="Uceda Renteria S" first="Sara" last="Uceda Renteria">Sara Uceda Renteria</name>
<affiliation wicri:level="1">
<nlm:affiliation>Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Virology Unit, 20122 Milan, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Virology Unit, 20122 Milan</wicri:regionArea>
<placeName>
<settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Bernazzani, Mara" sort="Bernazzani, Mara" uniqKey="Bernazzani M" first="Mara" last="Bernazzani">Mara Bernazzani</name>
<affiliation wicri:level="1">
<nlm:affiliation>Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Responsabile Infermieristico area Direzione Medica di Presidio, Coordinamento dipartimenti clinici, Servizio Prevenzione Igiene Ospedaliera, 20122 Milan, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Responsabile Infermieristico area Direzione Medica di Presidio, Coordinamento dipartimenti clinici, Servizio Prevenzione Igiene Ospedaliera, 20122 Milan</wicri:regionArea>
<placeName>
<settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Cantu, Anna Paola" sort="Cantu, Anna Paola" uniqKey="Cantu A" first="Anna Paola" last="Cantù">Anna Paola Cantù</name>
<affiliation wicri:level="1">
<nlm:affiliation>Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Direzione Medica di Presidio, 20122 Milan, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Direzione Medica di Presidio, 20122 Milan</wicri:regionArea>
<placeName>
<settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
<affiliation wicri:level="1">
<nlm:affiliation>Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Romeo ed Enrica Invernizzi Paediatric Research Centre, Department of Biosciences, University of Milan, 20122 Milan, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Romeo ed Enrica Invernizzi Paediatric Research Centre, Department of Biosciences, University of Milan, 20122 Milan</wicri:regionArea>
<placeName>
<settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Ceriotti, Ferruccio" sort="Ceriotti, Ferruccio" uniqKey="Ceriotti F" first="Ferruccio" last="Ceriotti">Ferruccio Ceriotti</name>
<affiliation wicri:level="1">
<nlm:affiliation>Fondazione IRCCS Ca' Granda Ospedale Maggiore, Clinical Laboratory, 20122 Milan, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Fondazione IRCCS Ca' Granda Ospedale Maggiore, Clinical Laboratory, 20122 Milan</wicri:regionArea>
<placeName>
<settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Lunghi, Giovanna" sort="Lunghi, Giovanna" uniqKey="Lunghi G" first="Giovanna" last="Lunghi">Giovanna Lunghi</name>
<affiliation wicri:level="1">
<nlm:affiliation>Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Virology Unit, 20122 Milan, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Virology Unit, 20122 Milan</wicri:regionArea>
<placeName>
<settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
</author>
</analytic>
<series>
<title level="j">International journal of environmental research and public health</title>
<idno type="eISSN">1660-4601</idno>
<imprint>
<date when="2020" type="published">2020</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc>
<textClass>
<keywords scheme="KwdEn" xml:lang="en">
<term>Adult (MeSH)</term>
<term>Aged (MeSH)</term>
<term>Betacoronavirus (isolation & purification)</term>
<term>Coronavirus Infections (epidemiology)</term>
<term>Coronavirus Infections (virology)</term>
<term>Female (MeSH)</term>
<term>Health Personnel (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Italy (epidemiology)</term>
<term>Male (MeSH)</term>
<term>Middle Aged (MeSH)</term>
<term>Pandemics (MeSH)</term>
<term>Pneumonia, Viral (epidemiology)</term>
<term>Pneumonia, Viral (virology)</term>
<term>Retrospective Studies (MeSH)</term>
<term>Young Adult (MeSH)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr">
<term>Adulte (MeSH)</term>
<term>Adulte d'âge moyen (MeSH)</term>
<term>Betacoronavirus (isolement et purification)</term>
<term>Femelle (MeSH)</term>
<term>Humains (MeSH)</term>
<term>Infections à coronavirus (virologie)</term>
<term>Infections à coronavirus (épidémiologie)</term>
<term>Italie (épidémiologie)</term>
<term>Jeune adulte (MeSH)</term>
<term>Mâle (MeSH)</term>
<term>Pandémies (MeSH)</term>
<term>Personnel de santé (MeSH)</term>
<term>Pneumopathie virale (virologie)</term>
<term>Pneumopathie virale (épidémiologie)</term>
<term>Sujet âgé (MeSH)</term>
<term>Études rétrospectives (MeSH)</term>
</keywords>
<keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en">
<term>Italy</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en">
<term>Coronavirus Infections</term>
<term>Pneumonia, Viral</term>
</keywords>
<keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en">
<term>Betacoronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr">
<term>Betacoronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr">
<term>Infections à coronavirus</term>
<term>Pneumopathie virale</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en">
<term>Coronavirus Infections</term>
<term>Pneumonia, Viral</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr">
<term>Infections à coronavirus</term>
<term>Italie</term>
<term>Pneumopathie virale</term>
</keywords>
<keywords scheme="MESH" xml:lang="en">
<term>Adult</term>
<term>Aged</term>
<term>Female</term>
<term>Health Personnel</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Pandemics</term>
<term>Retrospective Studies</term>
<term>Young Adult</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr">
<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Femelle</term>
<term>Humains</term>
<term>Jeune adulte</term>
<term>Mâle</term>
<term>Pandémies</term>
<term>Personnel de santé</term>
<term>Sujet âgé</term>
<term>Études rétrospectives</term>
</keywords>
<keywords scheme="Wicri" type="geographic" xml:lang="fr">
<term>Italie</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front>
<div type="abstract" xml:lang="en">
<i>Background</i>
: Coronavirus Disease 2019 (COVID-19) has rapidly spread worldwide, becoming an unprecedented public health emergency. Rapid detection of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) suspected cases is crucial to control the spread of infection. We aimed to evaluate the time length of negativization from the onset of symptoms in healthcare workers (HCWs) with COVID-19, and to evaluate significant variations in cycle threshold (CT) values and gene positivity (E, RdRP, and N genes) among positive individuals who returned to work.
<i>Methods</i>
: We retrospectively analyzed a consecutive cohort of 182 SARS-CoV-2-positive HCWs in Milan, from 16 March to 30 April 2020. Nasopharyngeal swabs were tested by RT-PCR.
<i>Results</i>
: Asymptomatic HCWs were 17.6% (32/182), and 58 healed at 30 April 2020. The median time length of negativization was 4 weeks (35% of symptomatic versus 40% of asymptomatic HCWs). Four HCWs, healed at 30 April, turned positive within three weeks during controls set up in the work unit. Three-gene positivity had the greatest variability, and increasing CT values from single- to three-gene positivity among all age groups were observed.
<i>Conclusions</i>
: Self-isolation longer than two weeks and prolonged follow-up periods for the staff returning to work after COVID-19 could be the most suitable choices to counter the SARS-CoV-2 spread. Further studies are needed to investigate infectiousness profiles among positive individuals.</div>
</front>
</TEI>
<pubmed>
<MedlineCitation Status="MEDLINE" IndexingMethod="Curated" Owner="NLM">
<PMID Version="1">32718008</PMID>
<DateCompleted>
<Year>2020</Year>
<Month>08</Month>
<Day>21</Day>
</DateCompleted>
<DateRevised>
<Year>2020</Year>
<Month>08</Month>
<Day>29</Day>
</DateRevised>
<Article PubModel="Electronic">
<Journal>
<ISSN IssnType="Electronic">1660-4601</ISSN>
<JournalIssue CitedMedium="Internet">
<Volume>17</Volume>
<Issue>15</Issue>
<PubDate>
<Year>2020</Year>
<Month>07</Month>
<Day>23</Day>
</PubDate>
</JournalIssue>
<Title>International journal of environmental research and public health</Title>
<ISOAbbreviation>Int J Environ Res Public Health</ISOAbbreviation>
</Journal>
<ArticleTitle>Time Length of Negativization and Cycle Threshold Values in 182 Healthcare Workers with Covid-19 in Milan, Italy: An Observational Cohort Study.</ArticleTitle>
<ELocationID EIdType="pii" ValidYN="Y">E5313</ELocationID>
<ELocationID EIdType="doi" ValidYN="Y">10.3390/ijerph17155313</ELocationID>
<Abstract>
<AbstractText>
<i>Background</i>
: Coronavirus Disease 2019 (COVID-19) has rapidly spread worldwide, becoming an unprecedented public health emergency. Rapid detection of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) suspected cases is crucial to control the spread of infection. We aimed to evaluate the time length of negativization from the onset of symptoms in healthcare workers (HCWs) with COVID-19, and to evaluate significant variations in cycle threshold (CT) values and gene positivity (E, RdRP, and N genes) among positive individuals who returned to work.
<i>Methods</i>
: We retrospectively analyzed a consecutive cohort of 182 SARS-CoV-2-positive HCWs in Milan, from 16 March to 30 April 2020. Nasopharyngeal swabs were tested by RT-PCR.
<i>Results</i>
: Asymptomatic HCWs were 17.6% (32/182), and 58 healed at 30 April 2020. The median time length of negativization was 4 weeks (35% of symptomatic versus 40% of asymptomatic HCWs). Four HCWs, healed at 30 April, turned positive within three weeks during controls set up in the work unit. Three-gene positivity had the greatest variability, and increasing CT values from single- to three-gene positivity among all age groups were observed.
<i>Conclusions</i>
: Self-isolation longer than two weeks and prolonged follow-up periods for the staff returning to work after COVID-19 could be the most suitable choices to counter the SARS-CoV-2 spread. Further studies are needed to investigate infectiousness profiles among positive individuals.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y">
<Author ValidYN="Y">
<LastName>Cariani</LastName>
<ForeName>Lisa</ForeName>
<Initials>L</Initials>
<AffiliationInfo>
<Affiliation>Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Microbiology Unit, 20122 Milan, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Orena</LastName>
<ForeName>Beatrice Silvia</ForeName>
<Initials>BS</Initials>
<Identifier Source="ORCID">0000-0003-4921-0757</Identifier>
<AffiliationInfo>
<Affiliation>Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Microbiology Unit, 20122 Milan, Italy.</Affiliation>
</AffiliationInfo>
<AffiliationInfo>
<Affiliation>Specialization School in Microbiology and Virology, University of Milan, 20142 Milan, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Ambrogi</LastName>
<ForeName>Federico</ForeName>
<Initials>F</Initials>
<Identifier Source="ORCID">0000-0001-9358-011X</Identifier>
<AffiliationInfo>
<Affiliation>Laboratory of Medical Statistics and Biometry, Giulio A. Maccacaro, Department of Clinical Sciences and Community Health, Campus Cascina Rosa, University of Milan, 20133 Milan, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Gambazza</LastName>
<ForeName>Simone</ForeName>
<Initials>S</Initials>
<Identifier Source="ORCID">0000-0002-6225-2989</Identifier>
<AffiliationInfo>
<Affiliation>Laboratory of Medical Statistics and Biometry, Giulio A. Maccacaro, Department of Clinical Sciences and Community Health, Campus Cascina Rosa, University of Milan, 20133 Milan, Italy.</Affiliation>
</AffiliationInfo>
<AffiliationInfo>
<Affiliation>UOC Direzione Professioni Sanitarie, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Maraschini</LastName>
<ForeName>Anna</ForeName>
<Initials>A</Initials>
<AffiliationInfo>
<Affiliation>Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Microbiology Unit, 20122 Milan, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Dodaro</LastName>
<ForeName>Antonella</ForeName>
<Initials>A</Initials>
<AffiliationInfo>
<Affiliation>Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Microbiology Unit, 20122 Milan, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Oggioni</LastName>
<ForeName>Massimo</ForeName>
<Initials>M</Initials>
<Identifier Source="ORCID">0000-0003-2709-6965</Identifier>
<AffiliationInfo>
<Affiliation>Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Virology Unit, 20122 Milan, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Orlandi</LastName>
<ForeName>Annarosa</ForeName>
<Initials>A</Initials>
<AffiliationInfo>
<Affiliation>Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Virology Unit, 20122 Milan, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Pirrone</LastName>
<ForeName>Alessia</ForeName>
<Initials>A</Initials>
<AffiliationInfo>
<Affiliation>Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Microbiology Unit, 20122 Milan, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Uceda Renteria</LastName>
<ForeName>Sara</ForeName>
<Initials>S</Initials>
<AffiliationInfo>
<Affiliation>Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Virology Unit, 20122 Milan, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Bernazzani</LastName>
<ForeName>Mara</ForeName>
<Initials>M</Initials>
<AffiliationInfo>
<Affiliation>Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Responsabile Infermieristico area Direzione Medica di Presidio, Coordinamento dipartimenti clinici, Servizio Prevenzione Igiene Ospedaliera, 20122 Milan, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Cantù</LastName>
<ForeName>Anna Paola</ForeName>
<Initials>AP</Initials>
<AffiliationInfo>
<Affiliation>Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Direzione Medica di Presidio, 20122 Milan, Italy.</Affiliation>
</AffiliationInfo>
<AffiliationInfo>
<Affiliation>Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Romeo ed Enrica Invernizzi Paediatric Research Centre, Department of Biosciences, University of Milan, 20122 Milan, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Ceriotti</LastName>
<ForeName>Ferruccio</ForeName>
<Initials>F</Initials>
<Identifier Source="ORCID">0000-0002-0958-5354</Identifier>
<AffiliationInfo>
<Affiliation>Fondazione IRCCS Ca' Granda Ospedale Maggiore, Clinical Laboratory, 20122 Milan, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Lunghi</LastName>
<ForeName>Giovanna</ForeName>
<Initials>G</Initials>
<AffiliationInfo>
<Affiliation>Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Virology Unit, 20122 Milan, Italy.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList>
<PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D064888">Observational Study</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic">
<Year>2020</Year>
<Month>07</Month>
<Day>23</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo>
<Country>Switzerland</Country>
<MedlineTA>Int J Environ Res Public Health</MedlineTA>
<NlmUniqueID>101238455</NlmUniqueID>
<ISSNLinking>1660-4601</ISSNLinking>
</MedlineJournalInfo>
<SupplMeshList>
<SupplMeshName Type="Disease" UI="C000657245">COVID-19</SupplMeshName>
<SupplMeshName Type="Organism" UI="C000656484">severe acute respiratory syndrome coronavirus 2</SupplMeshName>
</SupplMeshList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList>
<MeshHeading>
<DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D000073640" MajorTopicYN="N">Betacoronavirus</DescriptorName>
<QualifierName UI="Q000302" MajorTopicYN="Y">isolation & purification</QualifierName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName>
<QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D006282" MajorTopicYN="Y">Health Personnel</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D007558" MajorTopicYN="N" Type="Geographic">Italy</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D058873" MajorTopicYN="N">Pandemics</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D011024" MajorTopicYN="N">Pneumonia, Viral</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName>
<QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D012189" MajorTopicYN="N">Retrospective Studies</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D055815" MajorTopicYN="N">Young Adult</DescriptorName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM">
<Keyword MajorTopicYN="Y">Coronavirus Disease 2019</Keyword>
<Keyword MajorTopicYN="Y">Cycle Threshold values</Keyword>
<Keyword MajorTopicYN="Y">Reverse Transcription PCR</Keyword>
<Keyword MajorTopicYN="Y">SARS-CoV-2</Keyword>
<Keyword MajorTopicYN="Y">health care workers</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData>
<History>
<PubMedPubDate PubStatus="received">
<Year>2020</Year>
<Month>06</Month>
<Day>17</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="revised">
<Year>2020</Year>
<Month>07</Month>
<Day>17</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted">
<Year>2020</Year>
<Month>07</Month>
<Day>20</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez">
<Year>2020</Year>
<Month>7</Month>
<Day>29</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed">
<Year>2020</Year>
<Month>7</Month>
<Day>29</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline">
<Year>2020</Year>
<Month>8</Month>
<Day>22</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>epublish</PublicationStatus>
<ArticleIdList>
<ArticleId IdType="pubmed">32718008</ArticleId>
<ArticleId IdType="pii">ijerph17155313</ArticleId>
<ArticleId IdType="doi">10.3390/ijerph17155313</ArticleId>
<ArticleId IdType="pmc">PMC7432921</ArticleId>
</ArticleIdList>
<ReferenceList>
<Reference>
<Citation>Int J Infect Dis. 2020 May;94:154-155</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">32179137</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>N Engl J Med. 2020 Mar 26;382(13):1199-1207</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">31995857</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Mil Med Res. 2020 Mar 13;7(1):11</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">32169119</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>N Engl J Med. 2020 Feb 20;382(8):727-733</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">31978945</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>J Med Virol. 2020 May 8;:</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">32383182</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Clin Chim Acta. 2020 Jun;505:172-175</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">32156607</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Lancet. 2020 Mar 28;395(10229):1054-1062</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">32171076</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Virol J. 2019 May 27;16(1):69</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">31133031</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Nature. 2020 May;581(7809):465-469</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">32235945</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Eur Respir Rev. 2020 Apr 3;29(155):</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">32248146</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>J Autoimmun. 2020 May;109:102433</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">32113704</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Rev Esp Enferm Dig. 2020 May;112(5):383-388</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">32343593</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Eur J Clin Microbiol Infect Dis. 2020 May 28;:</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">32462501</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>BMJ. 2020 Apr 21;369:m1443</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">32317267</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Emerg Microbes Infect. 2020 Dec;9(1):747-756</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">32196430</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>BMJ. 2020 Mar 26;368:m1254</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">32217525</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>J Med Virol. 2020 Apr 9;:</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">32270882</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Antiviral Res. 2014 Mar;103:39-50</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">24418573</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>EClinicalMedicine. 2020 Apr 05;21:100331</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">32292899</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>J Clin Med. 2020 Apr 15;9(4):</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">32326602</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Nat Med. 2020 May;26(5):672-675</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">32296168</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Gastroenterology. 2020 May;158(6):1831-1833.e3</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">32142773</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Euro Surveill. 2020 Mar;25(10):</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">32183930</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
<affiliations>
<list>
<country>
<li>Italie</li>
</country>
<region>
<li>Lombardie</li>
</region>
<settlement>
<li>Milan</li>
</settlement>
</list>
<tree>
<country name="Italie">
<region name="Lombardie">
<name sortKey="Cariani, Lisa" sort="Cariani, Lisa" uniqKey="Cariani L" first="Lisa" last="Cariani">Lisa Cariani</name>
</region>
<name sortKey="Ambrogi, Federico" sort="Ambrogi, Federico" uniqKey="Ambrogi F" first="Federico" last="Ambrogi">Federico Ambrogi</name>
<name sortKey="Bernazzani, Mara" sort="Bernazzani, Mara" uniqKey="Bernazzani M" first="Mara" last="Bernazzani">Mara Bernazzani</name>
<name sortKey="Cantu, Anna Paola" sort="Cantu, Anna Paola" uniqKey="Cantu A" first="Anna Paola" last="Cantù">Anna Paola Cantù</name>
<name sortKey="Cantu, Anna Paola" sort="Cantu, Anna Paola" uniqKey="Cantu A" first="Anna Paola" last="Cantù">Anna Paola Cantù</name>
<name sortKey="Ceriotti, Ferruccio" sort="Ceriotti, Ferruccio" uniqKey="Ceriotti F" first="Ferruccio" last="Ceriotti">Ferruccio Ceriotti</name>
<name sortKey="Dodaro, Antonella" sort="Dodaro, Antonella" uniqKey="Dodaro A" first="Antonella" last="Dodaro">Antonella Dodaro</name>
<name sortKey="Gambazza, Simone" sort="Gambazza, Simone" uniqKey="Gambazza S" first="Simone" last="Gambazza">Simone Gambazza</name>
<name sortKey="Gambazza, Simone" sort="Gambazza, Simone" uniqKey="Gambazza S" first="Simone" last="Gambazza">Simone Gambazza</name>
<name sortKey="Lunghi, Giovanna" sort="Lunghi, Giovanna" uniqKey="Lunghi G" first="Giovanna" last="Lunghi">Giovanna Lunghi</name>
<name sortKey="Maraschini, Anna" sort="Maraschini, Anna" uniqKey="Maraschini A" first="Anna" last="Maraschini">Anna Maraschini</name>
<name sortKey="Oggioni, Massimo" sort="Oggioni, Massimo" uniqKey="Oggioni M" first="Massimo" last="Oggioni">Massimo Oggioni</name>
<name sortKey="Orena, Beatrice Silvia" sort="Orena, Beatrice Silvia" uniqKey="Orena B" first="Beatrice Silvia" last="Orena">Beatrice Silvia Orena</name>
<name sortKey="Orena, Beatrice Silvia" sort="Orena, Beatrice Silvia" uniqKey="Orena B" first="Beatrice Silvia" last="Orena">Beatrice Silvia Orena</name>
<name sortKey="Orlandi, Annarosa" sort="Orlandi, Annarosa" uniqKey="Orlandi A" first="Annarosa" last="Orlandi">Annarosa Orlandi</name>
<name sortKey="Pirrone, Alessia" sort="Pirrone, Alessia" uniqKey="Pirrone A" first="Alessia" last="Pirrone">Alessia Pirrone</name>
<name sortKey="Uceda Renteria, Sara" sort="Uceda Renteria, Sara" uniqKey="Uceda Renteria S" first="Sara" last="Uceda Renteria">Sara Uceda Renteria</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/CovidSeniorV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000121 | SxmlIndent | more

Ou

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000121 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    CovidSeniorV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     pubmed:32718008
   |texte=   Time Length of Negativization and Cycle Threshold Values in 182 Healthcare Workers with Covid-19 in Milan, Italy: An Observational Cohort Study.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:32718008" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a CovidSeniorV1 

Wicri

This area was generated with Dilib version V0.6.37.
Data generation: Thu Oct 15 09:49:45 2020. Site generation: Wed Jan 27 17:10:23 2021